CLCA2 as a p53-Inducible Senescence Mediator
نویسندگان
چکیده
منابع مشابه
Cystatin C as a p53‐inducible apoptotic mediator that regulates cathepsin L activity
In response to various cellular stresses, p53 is activated and inhibits malignant transformation through the transcriptional regulation of its target genes. However, the full picture of the p53 downstream pathway still remains to be elucidated. Here we identified cystatin C, a major inhibitor of cathepsins, as a novel p53 target. In response to DNA damage, activated p53 induced cystatin C expre...
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The basic leucine zipper transcription factor, CCAAT/enhancer binding protein alpha (C/EBPalpha), is abundantly expressed in keratinocytes of the skin; however, its function in skin is poorly characterized. UVB radiation is responsible for the majority of human skin cancers. In response to UVB-induced DNA damage, keratinocytes activate cell cycle checkpoints that arrest cell cycle progression a...
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ژورنال
عنوان ژورنال: Neoplasia
سال: 2012
ISSN: 1476-5586
DOI: 10.1593/neo.111700